Biocomparison Study

Inclusion Criteria: * Healthy men and women, aged between 20-80 years * Normal body weight and height (18.5 kg/m2 \< BMI \< 30 kg/m2) * Stable body weight (weight gain or loss \< 3 kg in past 3 mo) * Written consent to take part in the study * Agreement to adhere to dietary restrictions required by the protocol Exclusion Criteria: * Abuse of drugs and/or alcohol * Use of vitamin supplements containing vitamin K * Pregnancy * (a history of) metabolic or gastrointestinal diseases, e.g. hepatic or renal disorders, osteoporosis * Chronic degenerative and/or inflammatory diseases, e.g. diabetes mellitus, cancer, cardiovascular disease * Use of oral anticoagulants, drugs or hormones that influence bone metabolism * Corticoid treatment * Subjects with anaemia or subjects who recently donated blood or plasma * Systemic treatment or topical treatment likely to interfere with coagulation metabolism (salicylates, antibiotics)