Dose Finding Study Depigoid Phleum: 4 Doses in Patients With Allergic Rhinitis/Rhinoconjunctivitis +-Asthma

Inclusion Criteria: * appropriately signed and dated ICON prior to study specific action * IgE-mediated Sensitization against grass pollen * Perception of disease activity of at least 30 mm on a 100 mm VAS * FEV1 or a PEFR value \> 80% of predicted normal value * Allergic rhinitis and/or rhinoconjunctivitis symptoms (at least 2 years) with or without intermittent asthma symptoms verified by: * suggestive medical history AND * specific IgE against grass pollen with CAP-RAST ≥ 2 AND * a positive SPT (wheal diameter ≥ 3 mm) AND * a positive CPT for grass pollen * Patients with co-allergies are allowed to enter the study: * being asymptomatic against co-allergens such as tree or weed pollen, house dust mites, cat and dog, and other country specific allergens * with CAP-RAST co-allergen \< grass (detailed specifications given for Birch, HDM, animal dander, other country specific allergens) * All other co-allergens: difference in CAP RAST co-allergen to grass of ≥ 2 and an SPT wheal diameter co-allergen \< grass * Females of non-childbearing potential must be postmenopausal for at least 1 year or surgically sterilized * Females of childbearing potential must be non-lactating, non-pregnant and must correctly use an effective method of contraception during the study. Exclusion Criteria: * Acute or chronic infectious conjunctivitis * History of significant clinical manifestations of allergy as a result of sensitisation against trees or weed pollen and perennial a…