Combined Therapy in Radiation Proctopathy

Inclusion Criteria: * radiotherapy due to pelvic tumors completed at least three months prior to enrollment * presence of rectal bleeding * radiation-induced telangiectasia in the rectum and/or sigmoid colon on endoscopy * informed written consent to participate in the study Exclusion Criteria: * history of clinically significant rectal bleeding prior to radiotherapy * conditions predisposing the patient to rectal bleeding including inflammatory bowel disease, tumors of the large bowel, intestinal vascular lesions (other than radiation-induced telangiectasia), and diversion of the fecal stream * sucralfate treatment during the two weeks prior to enrollment * renal insufficiency (creatinine level ≥2 mg/dl) * concurrent chemotherapy * concurrent therapy with tetracycline, fluoroquinolones, or antimycotic drugs (because of drug interaction) * concurrent therapy with oral anticoagulants