The Effects of GLP-1 in Maturity-Onset Diabetes of The Young (MODY)

Inclusion Criteria: * Caucasian above 18 years of age * Well characterised MODY3 * Body mass index (BMI) \> 19 kg/m2 * Normal haemoglobin (males \> 8.2 mM, females \> 7.2 mM) * Normal blood pressure (\< 160/100 mmHg) * Informed consent * Capability to perform a light cycling test (heart rate 100-120 beats per minute during 30 minutes) * Females: use of anticonception (IUC or hormonal) Exclusion Criteria: * Heart failure: New York Heart Association class III-IV * Uraemia, end-stage renal disease, or any other cause of impaired renal function with s-creatinine \> 130 µM and/or albuminuria * Liver disease (alanine amino transferase (ALAT) and/or aspartate amino transferase (ASAT) \> 2 × upper normal serum levels) * Anaemia * Acute or chronic pancreatitis * Stroma or thyroid cancer * Pregnancy or breast feeding * Inability to complete the study * Treatment naïve patients with HbA1c \< 7.0 % * Treatment with medicine that can not be paused for 12 hours * Known allergic reaction to study medication * Intention to become pregnant * Unwillingness to complete the protocol