Study of Stress and Life Quality of Patients Participating in Clinical Trials Versus Patients Non Participating

Inclusion Criteria: * patient with solid tumor or recurrent hematologic cancer, treated by chemotherapy or targeted therapy evaluated every 2 or 3 cycles; except for clinical trials associating non drug treatment (radiotherapy, surgery...) * subject to a 1st, 2nd or 3rd line of antitumor treatment * a phase 2 open labeled study, * a phase 2 or 3 blind randomised study, * a phase 2 or 3 open randomised study, * a standard treatment non participating to a clinical trial * male or female patients ≥ 18 years of age * karnovsky ≥ 70 % or WHO (Performance Status) ≤ 2 * recovered from prior toxicities * social security covered * written informed consent given Exclusion Criteria: * psychiatric disorders, receiving psychotropic treatment * physical or psychological issues * forbidden to be included in this study