Safety,Effectiveness and Acceptability of Sino-implant II in DR

Inclusion Criteria:• In good general health * Aged between 18 and 44 years, inclusive * Not pregnant * Not lactating * Not wishing to become pregnant in the next five years * Request long-acting reversible contraception * If previously used injectable contraceptives for pregnancy prevention, be more than 9 months since last injection of Depo-Provera and more than 3 months after the last injection of a combined injectable contraceptive * If previously used LNG-containing oral pills or implants, be more than 1 week after last hormone intake or implant removal * Be able to understand the information provided and to make personal decisions on participation * Consent to participation and sign a consent form * Agree and be able to return to the clinic for follow-up visits over five years Exclusion Criteria: * acute deep venous thrombosis and/or pulmonary embolism or history of thromboembolic disease * systemic lupus erythematosus with positive or unknown antiphospholipid antibodies * unexplained vaginal bleeding * current or history of breast cancer * acute liver disease or cirrhosis * benign or malignant tumor of the liver * use of rifampicin, and/or anticonvulsants (barbiturates, phenytoin, phenobarbital, carbamazepine, oxcarbazepine, primidone, topiramate), and/or herbal products containing St. John's Wort (Hypericum perforatum) * more than one sexual partner in the last 3 months * diagnosis or treatment for a sexually transmitted infection (STI) within the past 30 days for h…