Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter (NCT01588288) | Clinical Trial Compass
CompletedNot Applicable
Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter
France193 participantsStarted 2012-09
Plain-language summary
The investigators will dose galectin 3 in plasma and water rinse of the needle aspiration biopsy in patients with thyroid nodules. The investigators aim to show that preoperative dosage of the galectin 3 could provide good diagnosis of malignant versus benign thyroid cancer.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Men and women
* 18 years old or more
* Patient with one or more thyroid nodules with the following definition :
A nodule is a circumscribed intraparenchymal expansive development. This is thus a structure that appears on two cuts perpendicular ovoid. a nodule is visible on ultrasound by their mass effect (contour deformation), its ultrasound contrast relative to adjacent parenchyma or by repression of vascular structures at its periphery (halo and cantilever)
* Indication for a cytopuncture, in the opinion of the investigator
* Definitive postoperative histological analysis confirming a benign or malignant tumor of vesicular lineage cells.
* Patient affiliated to the french public welfare system
* Patient who signed an informed consent
Exclusion Criteria:
* Simple goiter
* Thyroid dysfunction
* Hashimoto's thyroiditis
* Basedow's disease
* No surgery at the end of the study
* After definitive postoperative histological analysis : lymphoma, medullary thyroid carcinoma, anaplastic thyroid cancer, or focal Hashimoto's thyroiditis
* Pregnancy
* Major under guardianship,
* Person deprived from him administrative and judicial liberty
What they're measuring
1
Sensitivity (Se) and specificity (Sp) of plasmatic galectin 3 dosage in preoperative