The Effects of Sodium and Potassium on Blood Pressure, Vascular Function and Renal Function (NCT01575041) | Clinical Trial Compass
CompletedNot Applicable
The Effects of Sodium and Potassium on Blood Pressure, Vascular Function and Renal Function
Netherlands40 participantsStarted 2012-01
Plain-language summary
To determine the effect of (1) increased sodium intake and (2) increased potassium intake on blood pressure, vascular function and renal function in untreated (pre)hypertensive subjects.
Who can participate
Age range40 Years – 90 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* (Pre)hypertension, defined as office SBP: 130-159 mmHg;
* No use of antihypertensive, lipid-lowering, anticoagulant or other cardiovascular medication;
* Age at start of the ≥ 40 years;
* Apparently healthy:
* No reported current or previous metabolic diseases
* No history of cardiovascular diseases
* No history of renal, liver or thyroid diseases
* No history of gastrointestinal diseases
* No diabetes mellitus
* Fasting laboratory parameters within normal range: renal function (serum creatinine, ureum), liver function (ALAT, ASAT, ɣ-GT) and serum glucose.
Exclusion Criteria:
* Body mass index \> 40 kg/m²;
* Smoking
* Secondary hypertension;
* Weight loss or weight gain of 5 kg or more during the last 2 months;
* Usage of non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, naproxen) and not able or willing to stop taking them from at least 4 weeks prior to the study.
* Medical treatment that may affect blood pressure and not able (or willing) to stop taking them;
* Women taking oral contraceptives or estrogen replacement therapy
* Taking nutritional supplements and unwilling to discontinue;
* Women lactating, pregnant or intend to become pregnant during study;
* Reported dietary habits: medically prescribed diet, slimming diet;
* Reported alcohol consumption \> 21 units/w (female subjects) or \>28 units/w (male subjects);
* Unable or unwilling to consume one meal every workday at the university, or to consume the prescribed study d…
What they're measuring
1
Change in Endothelium-dependent flow-mediated dilation comparing (1) high sodium, low potassium intake and (2) low sodium, high potassium intake with low sodium, low potassium intake.
Timeframe: Baseline at week 1 (t=0). After intervention period 1 at week 5 (t=1). After intervention period 2 at week 9 (t=2). After intervention period 3 at week 13 (t=3)