Crossover Study of CNV1014802 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy

Key Inclusion Criteria: * Male or female aged between 18 and 65 years, with a diagnosis of neuropathic pain due to lumbosacral radiculopathy (LSR). * Female subjects must be of non-child bearing potential or agree to use an approved form of contraception * Body weight \< 50 kg for men and \< 45 kg for women. * Capable of giving written informed consent. * Approved concomitant medications must have been stable for at least 4 weeks prior to day 1. * Average baseline daily pain score for neuropathic pain due to LSR on the 11-point numerical rating scale of 4 or greater. Key Exclusion Criteria: * Subjects who are unable to reliably delineate or assess their own pain by anatomical location/distribution. * Subjects with lumbar canal stenosis in which the pain in the lower limbs occur solely on walking and not at rest. * Subjects with causes for their neuropathic pain other than LSR. * Subjects who have received nerve blocks and/or steroid injections for neuropathic pain within 4 weeks prior to day 1. * Subjects who are indicated for surgical treatment of lumbosacral radiculopathy. * A positive pre-study drug screen. * A positive history of HIV. * A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening. * History of any liver disease within the last 6 months, with the exception of known Gilbert's disease. * History of excessive regular alcohol consumption within 6 months of the study. * Subjects with a history or risk …