The need exists for alternatives to 99mTc based perfusion radiotracers for cardiac patient management. An alternative radiotracer, I123-CMICE-013, has been developed at the Canadian Molecular Imaging Center of Excellence (C-MICE) at the University of Ottawa Heart Institute. Initial testing results in rats and pigs suggest that in addition to being a cyclotron-produced alternative to 99mTc tracers, I-123-CMICE-013 may be a superior tracer for measuring myocardial perfusion.This Phase 1 study will study the safety and tolerability, biodistribution, pharmacokinetics and radiation dosimetry, and distribution and localization of I123-CMICE-013in healthy adult volunteers.
Age range
18 Years – 65 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Biodistribution of the 123I-CMICE-013 Within the Lungs
Timeframe: From enrollment to completion of imaging was 24 hours for each scan. Rest and stress scans were performed one week apart.
Biodistribution of the 123I-CMICE-013 Within the Thyroid
Timeframe: From enrollment to completion of imaging was 24 hours for each scan. Rest and stress scans were performed one week apart.
Biodistribution of the 123I-CMICE-013 Within the Heart Wall
Timeframe: From enrollment to completion of imaging was 24 hours for each scan. Rest and stress scans were performed one week apart.
Biodistribution of the 123I-CMICE-013 Within the Bladder
Timeframe: From enrollment to completion of imaging was 24 hours for each scan. Rest and stress scans were performed one week apart.
Biodistribution of the 123I-CMICE-013 Within the Liver
Timeframe: From enrollment to completion of imaging was 24 hours for each scan. Rest and stress scans were performed one week apart.