Paired Associative Stimulation in the Dorsolateral Prefrontal Cortex in Patients With Schizophrenia (NCT01545999) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Paired Associative Stimulation in the Dorsolateral Prefrontal Cortex in Patients With Schizophrenia
Canada72 participantsStarted 2012-03
Plain-language summary
The purpose of this study is to
1. assess the effect of PAS in schizophrenia in the dorsolateral prefrontal cortex (DLPFC)
2. assess the effect of PAS induced long-term potentiation (LTP) on the performance of patients with schizophrenia on a cognitive task related to DLFPC.
Who can participate
Age range18 Years – 60 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria for patients:
* Age 18 or above
* All races and ethnicities.
* Females and males.
* Meet DSM-IV TR criteria for a current diagnosis of schizophrenia or schizoaffective disorder.
* Clinically stable as operationalized by (1) either having not been hospitalized within 3 months or having been hospitalized for 3 months or more prior to assessment, and (2) having had no change in antipsychotic medication dosage within the 4 weeks prior to assessment.
* Willingness and ability to speak English
* Willingness to provide informed consent
* Corrected visual ability that enables reading of newspaper headlines and corrected hearing capacity that is adequate to respond to a raised conversational voice.
Exclusion Criteria for patients:
* Meets criteria for a cognitive disorder secondary to a neurological or other medical disorder affecting the central nervous system (for example, multiple sclerosis, history of traumatic brain injury, stroke, untreated hypothyroidism).
* Mini Mental Status Examination score of 17 and less because a subject with a very low MMSE score is unlikely to be able to compete the NP battery.
* Diagnosis of bipolar disorder or current major depressive episode.
* Meets diagnostic criteria for current alcohol or other drug dependence within 6 months of testing
* Electroconvulsive Therapy (ECT) within 6 months of testing.
* Left handedness.
* Incompetency to consent
Inclusion Criteria for controls:
* Age 18 or above
* Willingness and ability to sp…