Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MDCO-2010 in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery

Inclusion Criteria * Men, aged 18 to 80 years or * Post-menopausal women, aged up to 80 years. Postmenopausal status defined as ≥ 1 year since last menstruation in women with no medical history of hysterectomy or women with a medical history of bilateral oophorectomy * Planned elective, isolated primary CABG surgery with more than 1 graft, including the use of cardiopulmonary bypass * Written informed consent prior to any study-related procedure not part of normal medical care Exclusion Criteria Patients may not meet any of the following exclusion criteria: * Planned concomitant surgery including atrial septal defect (ASD) repair, valve replacement, carotid endarterectomy, aortic surgery, any combined procedure or any repeat sternotomy * Planned Off-pump CABG * Body weight \< 55 kg or \> 110 kg * Planned hypothermia \< 28°C * Major surgical procedures within 30 days of entry * Placement of drug-eluting stent (DES) within 12 months or of bare-metal stent (BMS) within 6 weeks of entry in a vessel which is not intended to be grafted * Ejection fraction \< 35% * Preoperative coagulation abnormalities * Platelet count \< 100,000/cubic mm, or * INR \> 1.5 or Quick \< 40%, or * activated partial thromboplastin time (aPTT) \> 1.5 x upper limit of normal (ULN) * Preoperative Hb \< 11 g/dL for male patients or \< 10 g/dL for female patients * Patient refusal to receive donor blood products if necessary * Administration of thienopyridines within 5 days prior to surgery Admini…