The aim of this trial is to assess the effect of hydrolyzed egg orally administered on oral tolerance induction to egg in children allergic to egg as compared to a placebo.
Who can participate
Age range12 Months – 66 Months
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Child of any ethnicity aged between 12 and 66 months at the time of enrolment
* Positive Skin Prick Test (SPT) to egg white within the last 3 months
* Either positive oral challenge OR convincing history, defined as an immediate (\<1h) reaction following isolated ingestion of egg, positive SPT to egg white and positive sIgE (\> 0.35 kU/L) for at least one of the following: egg, egg white, ovalbumin, ovomucoid, within the last 12 months
* Having obtained his/her signed legal representative's informed consent.
Exclusion Criteria:
* History of severe anaphylaxis to egg
* Significant pre-natal and/or post-natal disease
* Child on systemic drugs (e.g. antihistamines, beta-agonists, ACE-inhibitors) according to half-life at time of enrolment
* Congenital illness or malformation that may affect normal growth (especially immunodeficiency)
* Child whose parents / caregivers cannot be expected to comply with treatment
* Child currently participating in another interventional clinical trial
What they're measuring
1
positive or negative result (objective and subjective symptoms) of a challenge test with egg