The study will primarily assess the antitumor activity of crizotinib in a variety of tumors with alterations in ALK and/or MET pathways. The targeted patient population will include patients with tumors harboring specific alterations leading to ALK and/or MET activation, where tyrosine kinase inhibitors against these targets have not yet been adequately explored.
Who can participate
Age range1 Year
SexALL
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General inclusion criteria:
* Locally advanced and/or metastatic anaplastic large cell lymphoma
* Locally advanced and/or metastatic inflammatory myofibroblastic tumor
* Locally advanced and/or metastatic papillary renal cell carcinoma type 1
* Locally advanced and/or metastatic alveolar soft part sarcoma
* Locally advanced and/or metastatic clear cell sarcoma
* Locally advanced and/or metastatic alveolar rhabdomyosarcoma.
* The above malignancies must be incurable by conventional surgery, radiotherapy, systemic therapy or any other means.
* Proven presence of specific ALK and/or MET pathway alteration in tumor tissue is not mandatory for patient registration.
* Availability of tumor material for central pathology review
* Written informed consent
* Measurable disease according to RECIST 1.1
* Patients with brain metastases are eligible if treated and/or neurologically stable with no ongoing requirement for corticosteroids (off steroids for at least 2 weeks) and not taking contraindicated medications. Absence of spinal cord compression unless treated with the patient attaining good pain control and stable or recovered neurologic function.
* No carcinomatous meningitis or leptomeningeal disease.
* Any previous systemic anticancer therapy must have been completed at least 4 weeks prior to initiation of study medication.
* No treatment with any other investigational drug within the past 4 weeks or within less than 4 half-life times of the investigational drug before treatment w…
What they're measuring
1
Antitumor activity of crizotinib
Trial details
NCT IDNCT01524926
SponsorEuropean Organisation for Research and Treatment of Cancer - EORTC