The objective of this study is to evaluate the efficacy and tolerability of adding anacetrapib to ongoing statin therapy in participants with heterozygous familial hypercholesterolemia (HeFH).
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Percent Change From Baseline in Low-Density Lipoprotein Cholesterol (LDL-C) - Treatment Phase
Timeframe: Baseline and Week 52
Percentage of Participants With Any Adverse Event - Treatment Phase
Timeframe: Up to 52 weeks
Percentage of Participants With Any Treatment-Related Adverse Event - Treatment Phase
Timeframe: Up to 52 weeks
Percentage of Participants With Any Serious Adverse Event - Treatment Phase
Timeframe: Up to 52 weeks
Percentage of Participants Discontinuing Study Treatment Due to an Adverse Event - Treatment Phase
Timeframe: Up to 52 weeks
Percentage of Participants With Changes in Systolic Blood Pressure (SBP) >= 10 mm Hg
Timeframe: Up to 52 weeks
Percentage of Participants With Changes in SBP >= 15 mm Hg
Timeframe: Up to 52 weeks
Percentage of Participants With Changes in Diastolic Blood Pressure (DBP) >= 10 mm Hg
Timeframe: Up to 52 weeks
Percentage of Participants With Sodium Levels > Upper Limit of Normal (ULN)
Timeframe: Up to 52 weeks
Percentage of Participants With Chloride Levels > ULN
Timeframe: Up to 52 weeks
Percentage of Participants With Potassium Levels < Lower Limit of Normal (LLN)
Timeframe: Up to 52 weeks
Percentage of Participants With Bicarbonate Levels > ULN
Timeframe: Up to 52 weeks
Percentage of Participants With Consecutive Changes in Alanine Aminotransferase (ALT) and/or Aspartate Aminotransferase (AST) of >=3 x ULN
Timeframe: Up to 52 weeks
Percentage of Participants With Creatine Kinase (CK) Level >=10 x ULN
Timeframe: Up to 52 weeks
Percentage of Participants With CK Level >=10 x ULN With Muscle Spasms
Timeframe: Up to 52 weeks
Percentage of Participants Adjudicated Cardiovascular (CV) SAE
Timeframe: Up to 52 weeks
Percentage of Participants Who Died From Any Cause - Treatment Phase
Timeframe: Up to 52 weeks