A Study of Safety, Tolerability, and Efficacy of AFN-12520000 in the Treatment of Acute Bacterial Skin and Skin Structure Infections Due to Staphylococci

Inclusion Criteria: * Provide written informed consent and to understand the demands of the protocol; * Ages of 18 and 70 years, inclusive; * Have clinically documented ABSSSI suspected or documented to be caused by staphylococci accompanied by redness, edema, and/or induration of a minimum surface area of 75 cm2 and can be categorized as one or more of the following: Wound infection; Cutaneous abscess Burn infection (≤20% of total body surface area) or Cellulitis * Have a primary infected lesion with at least three of the following: Significant pain or tenderness to palpation; Purulent or seropurulent drainage or discharge; Erythema; Fluctuance; Induration; Edema; Heat or localized warmth; * Have at least two of the following signs and symptoms of systemic inflammation or complicating factors: Documented or reported fever \>38.0°C; WBC count of \>10,000 cells/mm3; Greater than 15% immature neutrophils irrespective of total WBC; Elevated CRP or ESR; or Local/regional lymphadenopathy; * Have a Gram stain with Gram-positive cocci in clusters or PCR result indicating an infection with Staphylococci. * Have clearly failed as defined in the protocol previous treatment after a minimum of 48 hours * Women of childbearing potential must have a negative pregnancy test at screening before enrollment * Male and Female patients must utilize a highly effective method of contraception * In the judgment of the Investigator have an expectation of survival and prompt improvement with effecti…