Enhancing Breast Milk Production With Domperidone in Mothers of Preterm Neonates

Inclusion Criteria: * mothers of a preterm infant born \< 30 completed weeks gestation (23 0/7-29 6/7 weeks) * postpartum period of 7-21 days * mechanically pumping a minimum average of 6 times a day in the 4-7 days prior to enrollment * experiencing inadequate milk supply defined as providing \< 100% of the average of the daily nutritional intake during the previous 72-hour period prior to enrollment based on a fluid intake of 250 mL/kg/d or experiencing a clinical reduction of approximately 20% from a peak volume during the previous 72-hour period prior to enrollment Exclusion Criteria: * history of known or suspected cardiac dysrhythmias (tachyarrhythmia, Q-Tc prolongation) or currently on an anti-arrhythmic medication * currently experiencing mastitis * previous breast surgery, including augmentation or reduction, nipple piercing and/or the use of nipple rings/studs within the last year, or any reduction * known chronic or debilitating illness, known abnormal liver function or gastric abnormalities gastrointestinal that will be exacerbated by the use of a prokinetic, examples include hemorrhage or blockage, actively treated with acid reflux which requires treatment for greater than 5 days and includes H2 blockers (occasional use of H2 blockers for heartburn or mild acid reflux is not considered an exclusion) and HIV * known to have a prolactin-releasing pituitary tumor * receiving medications known to alter the metabolism and pharmacokinetics of domperidone (eg. oral "…