Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure

Inclusion Criteria: * Men and non-pregnant, non-lactating women 45 years of age or older * Able to give informed consent and complete scheduled visits * Mild-moderate bilateral lower extremity peripheral arterial disease as defined by an ankle-brachial index (ABI measurement of 0.6-0.9. If a subject has baseline claudication symptoms, the symptoms must be stable for the 3 months preceding enrollment. * History of hypertension. Blood pressure at the screening visit must be ≤160/100 mmHg and ≥100/60 mmHg for all subjects. If a subject is currently prescribed beta-blocker therapy, BP at the screening visit must be ≤140/90 mmHg. In addition, heart rate must be ≥55 beats per minute if currently prescribed a beta-blocker and ≤60 beats per minute if not currently prescribed a beta-blocker. * At least moderate risk for CAD. Exclusion Criteria: * Participation in another clinical trial * Ongoing ischemic (resting) limb pain, or lower extremity ulceration due to arterial insufficiency, or an ABI indicating \<0.6 indicating disease potentially requiring revascularization * History of limb or digit amputation due to arterial insufficiency * Revascularization of peripheral vessels within the preceding 6 months * Uncontrolled hypertension as defined by systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg * Contraindication or allergy to beta blocker therapy * History of myocardial infarction , coronary revascularization, or a cerebrovascular event within the preceding…