Opioid Induced Swallowing Difficulties and Risk for Pulmonary Aspiration (NCT01495377) | Clinical Trial Compass
CompletedPhase 4
Opioid Induced Swallowing Difficulties and Risk for Pulmonary Aspiration
Sweden25 participantsStarted 2012-01
Plain-language summary
The purpose of this study is to determine weather remifentanil induced swallowing difficulties increase risk for pulmonary aspiration.
Who can participate
Age range18 Years – 40 Years
SexALL
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Inclusion Criteria:
* 18 - 40 year old healthy volunteers from both sexes.
* Have signed and dated Informed Consent.
* Willing and able to comply with the protocol for the duration of the trial.
Exclusion Criteria:
* Pharyngoesophageal dysfunction
* Anamnesis of pharyngoesophageal dysfunction
* Known history of cardiac, pulmonary or neurological disease
* Ongoing medication
* Allergies to or history of reaction to naloxone, remifentanil, fentanyl analogues or other ingredients
* History of reaction to products containing human albumine
* Pregnancy or breast feeding
* BMI \> 30
* Previous participation in a medical clinical trial where opioid has been used or have during last 30 days participated in any other medicinal clinical trial or in a trial where follow-up in not completed
What they're measuring
1
Radioactivity evident in lungs imaged using a gamma camera
Timeframe: one study occasion takes two hours and a gamma camera scan is taken in the end of the occasion