For patients with Immunoglobulin E (IgE)-mediated food allergy, the current management includes identification of the causative food and avoidance. Egg allergy is among the most common causes of IgE-mediated food allergy in children, affecting approximately 1.6% of children (its prevalence is higher in children with atopic dermatitis or other food allergies). Given the prevalence of egg and the difficulty to avoid it in the diet, we aim to investigate the safety and efficacy of baked egg oral immunotherapy.
Who can participate
Age range6 Years – 17 Years
SexALL
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Inclusion criteria
✓. Subjects must be age six to 17 years and have a history of egg allergy. Subjects shall maintain strict avoidance of consumption of all egg protein containing foods.
✓. Subjects will have a history (within the past six months) of a positive skin prick test to egg extract or an immunocap IgE level greater than 0.35 kU/L, and a positive allergic reaction history to egg within the past 12 months.
✓. Subjects must be in good health, as determined by medical history and physical examination performed by a study physician.
✓. Females of childbearing potential must be using an effective method of contraception, including abstinence, and agree to continue to practice an acceptable method of contraception for the duration of their participation in the study.
✓. Informed consent of parent or legal guardian is required.
Exclusion criteria
✕. Ability to tolerate baked goods containing egg or the ability to tolerate a serving size of egg (6.3 grams of egg protein.)
✕. Pregnancy.
✕. A history of food protein induced enterocolitis syndrome to egg.
✕. A history of eosinophilic esophagitis, where egg has been identified as a causative food.
✕. A history of anaphylaxis requiring overnight hospitalization.
✕. A history of intubation related to asthma and/or a history of an intensive care unit admission for asthma management.
✕. A current diagnosis of severe persistent asthma \[FEV1 (forced expiratory volume in 1 second) \< 60% of predicted, as defined by NHLBI (National Heart, Lung, and Blood Institute) guidelines, despite current therapy\].
✕. A current diagnosis of severe atopic dermatitis.