Preventing Pain After Heart Surgery (NCT01480765) | Clinical Trial Compass
CompletedPhase 4
Preventing Pain After Heart Surgery
United Kingdom150 participantsStarted 2011-12-12
Plain-language summary
The use of pre-emptive analgesia to prevent pain following sternotomy for cardiac surgery
Who can participate
Age range18 Years – 80 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Informed Consent
* First time sternotomy for all cardiac surgery
* Patient aged 18 - 80 years
Exclusion Criteria:
* Emergency surgery (decision to operate taken on the day of surgery)
* Previous sternotomy
* Preoperative renal failure (eGFR \<60 ml/min)
* History of chronic non-anginal pain
* Chronic pain medication other than paracetamol and non-steroidal anti-inflammatory drugs
* Concurrent use of oxycodone, lorazepam, or ethanol.
* Concurrent use of any drugs for neuropathic pain e.g. antiepileptics, antidepressants
* Allergy to pregabalin, gabapentin or ketamine
* Pregnancy
* Limited understanding of numerical scoring scales
* Previous participation in other trials investigating analgesic agents or any IMP in previous three months
What they're measuring
1
Numerical Rating Scale (NRS) pain score (around sternotomy incision site) post surgery, at rest and following 3 maximal coughs.