This is a clinical study to assess the safety, tolerance and immunogenic response to MCV4(quadrivalent meningococcal polysaccharide conjugate, meningococcal serogroups A,C,Y, and W135), Tdap (diphtheria, tetanus, and acellular pertussis), and bivalent rLP2086 vaccine. Healthy male and female subjects, between the ages of 10 to 12 years old, will be randomized into 1 of 3 groups. The subjects, investigators, site staff and sponsor will be blinded to all injections given throughout the study. An unblinded administrator will be responsible to administer the vaccinations to all subjects and will be unblinded to the subject randomization in order to determine which subjects were in randomized to group 3 so they may receive their catch-up vaccinations of MCV4 and Tdap. A final telephone contact will be conducted with all subjects 6-months post their last vaccination to obtain safety information.
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Geometric Mean Concentrations (GMC) for Diphtheria and Tetanus Antigens
Timeframe: 1 Month after Vaccination 1
Geometric Mean Concentrations (GMC) for Acellular Pertussis Antigens
Timeframe: 1 Month after Vaccination 1
Geometric Mean Titer (GMT) for Meningococcal Conjugate Vaccine (MCV4) Antigens
Timeframe: 1 Month after Vaccination 1
Serum Bactericidal Assay Using Human Complement (hSBA) GMTs of PMB80 [A22] and PMB2948 [B24] 1 Month After Vaccination 3
Timeframe: 1 Month after Vaccination 3