STAGES Trial: Study of Adiposity, Growth and Endocrine Stages (NCT01460784) | Clinical Trial Compass
CompletedNot Applicable
STAGES Trial: Study of Adiposity, Growth and Endocrine Stages
United States575 participantsStarted 2010-06
Plain-language summary
The investigators propose to conduct a cross-sectional study of 60 participants who are 18-30 years of age to undergo research PET/CT. The purpose of this study is to investigate the relationships between Brown Adipose Tissue (BAT), the adiponectin/leptin (A/L) ratio, and components of the metabolic syndrome in young adults.
Who can participate
Age range18 Years – 30 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Males and females, 18-30 years of age at enrollment, who are obese (BMI greater or equal to 30 kg/m2, weight less than 159 kg) and healthy
* Without medications and endocrine/genetic disorders known to affect weight.
* Participants may have insulin resistance, impaired glucose tolerance, dyslipidemia, or hypertension.
Exclusion Criteria:
* Anyone who refuses participation.
* A genetic syndrome or other endocrine disorder known to cause obesity (Prader-Willi, Cushing Syndrome, Leptin deficiency, etc.).
* Use of the following medications: psychotropics, sulphonylurea, thiazolidinediones, insulin, glucocorticoids, anti-neoplastic agents, angiotensin receptor blocker, angiotensin-converting enzyme inhibitors.
* Pregnancy or history of pregnancy.
* Active infectious disease
* History of CVD or stroke during the previous 36 months
* Total cholesterol 300 mg/dl, triglycerides 400 mg/dl
* Blood pressure 140/90 mmHg
* Fasting plasma glucose 126 mg/dl.
* Diabetes mellitus, type 1 or 2.