Efficacy of Zylet vs. Lotemax for the Treatment of Ocular Surface Inflammation/MGD/Blepharitis

Inclusion Criteria: * Male or female * At least 18 years of age * Has not worn contact lenses, except for bandage contact lens or rigid gas permeable lens, for at least 2 weeks prior to the study and agrees to not wear contact lenses during study * Patient is in generally good \& stable overall health * Minimum corneal fluorescein staining of 4 in at least one eye * OSDI score \>22 * The patient must have a diagnosis of posterior blepharitis * A negative urine pregnancy test result for women of childbearing potential * Women of childbearing potential must agree to use adequate contraception (hormonal or barrier method of birth control) prior to study entry and for the duration of study participation. * Normal lid position and closure * Ability to understand and provide informed consent to participate in this study * Willingness to follow study instructions and likely to complete all required visits Exclusion Criteria: * History of Stevens-Johnson syndrome or ocular pemphigoid * History of eyelid surgery * Intra-ocular surgery or ocular laser surgery within 3 months * History of microbial keratitis, including herpes * Active ocular allergies * Corneal epithelial defect \> 1mm2 * Any change in use of topical anti-inflammatories, such as steroids, Restasis, or NSAID within the past 2 weeks * Any change in dosage of tetracycline compounds (tetracycline, doxycycline, and minocycline) within the past two weeks * Use of isotretinoin (Accutane) within the past 6 months * Pregnant …