Safety and Effects of Autologous Adipose-Derived Stromal Cells in Patients With Diffuse Lesions in the Brain

Inclusion Criteria: * Males and Females between Age 18 and 80 years. * Patient with current diagnosis of Diffuse Brain Lesions with cognitive and/or functional impairment * MRI not showing gross atrophy or any other pathology of brain. * Up to date on all age and gender appropriate cancer screening per American Cancer Society Exclusion Criteria: * Contraindication for MRI * General medical contraindications for minor surgery or angiography * Females who are pregnant or nursing or females of childbearing potential who are unwilling to maintain contraceptive therapy for the duration of the study * Life expectancy \< 6 months due to concomitant illnesses. * Exposure to any investigational drug or procedure within 1 month prior to study entry or enrolled in a concurrent study that may confound results of this study. * Active infectious disease. Patients known to have tested positive will have an expert consulted as to patient eligibility based on the patient's infectious status * Any illness which, in the Investigator's judgment, will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results * Patients on chronic immunosuppressive transplant therapy * Systolic blood pressure (supine) ≤90 mmHg; * Resting heart rate \> 100 bpm; * Active clinical infection within one week of enrollment. * Known drug or alcohol dependence or any other factors which will interfere with the study conduct or …