Safety and Efficacy of POL6326 for Mobilization/Transplant of Sibling Donor in Patients With Hematologic Malignancies

Donor Inclusion Criteria * Donor must be 18 to 70 years of age inclusive. * Donor must be a 6/6 HLA-matched sibling willing to donate PBSC for transplant. * Donor must have adequate cardiac function with no history of congestive heart failure and no history of atrial fibrillation or ventricular tachyarrhythmia. * Donor must have adequate renal function as defined by a minimum creatinine clearance (CrCl) value of \>30 ml/min. * Donor must have adequate hepatic function as defined by a total bilirubin \<3x upper limit of normal. * Donor must have adequate neurologic function as defined by NO evidence of a severe central or peripheral neurologic abnormality and no history of cerebrovascular accident or seizure disorder requiring anticonvulsant medication. * Donor must be HIV-1\&2 antibody and HTLV-1\&2 antibody sero-negative by FDA licensed test. * Donor must have an ECOG performance status of 0 or 1. * Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control, abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she must inform her treating physician immediately. * Donor must demonstrate ability to be compliant with study regimen. * Donor must be able to understand and willing to sign an IRB approved written informed consent document. Recipient Inclusion Criteria * Recipient must have availa…