Efficacy and Safety of Levetiracetam in Partial Seizures Control, With or Without Secondary Generalization

Inclusion Criteria: * Patients of both sexes, aged between 04 and 65 years, remaining the feasibility of a legal guardian in accordance with need, able to understand and provide written informed consent and able to allow compliance at the treatment and the requirements of the protocol; * Patient´s weight ≥ 20kg; * Consistent diagnosis of refractory focal epilepsy, with or without secondary generalization; * Patient with onset of seizures for at least 02 years preceding the screening visit; * Presence at least 12 partial seizures during the 03 months preceding the screening visit (04 seizures per month); * Only seizures that generate motor manifestation will be recorded in this study. * Absence of brain injury progressive or expansive, previously documented by CT scan, MRI or other imaging test applicable (in the last 05 years; * Patient with electroencephalogram performed up to 02 years before this visit; * Subject with stable regimen (minimum of 01 month) from one to three antiepileptic drugs. * Vagus nerve stimulation for 04 weeks prior to V1, or use of benzodiazepines for more than 07 consecutive days will be considered as concomitant epileptic drugs) Exclusion Criteria: * Patients with: * Seizures of non epileptic origin; * Pseudoseizures; * Seizures occurring in clustered patterns (03 or more seizures in 30 minutes), in the 03 months preceding the screening visit (V1); * History of status epilepticus while taking antiepileptic drugs during the 03 months…