Dose Escalation Trial of a Plague Vaccine, Flagellin/F1/V, in Healthy Adult Volunteers

Inclusion Criteria: Inclusion criteria that must met prior to the initial vaccination: * At least 18 and less than or equal to 45 years of age at the time of first vaccination. * Never had plague or disease caused by Yersinia pestis. * Able to provide informed consent. * Read, signed, and dated informed consent document. * Available for follow-up for the planned duration of the study. * Satisfactory medical assessment with no clinically significant and relevant abnormalities as established by medical history and physical examination at screening. * If the subject is female and of childbearing potential, negative serum pregnancy test at screening and negative urine or serum pregnancy test within 24 hours prior to each vaccination. * If the subject is female and of childbearing potential, she agrees to use acceptable contraception and remain on the same method during the study as they were using prior to entering the study, and not become pregnant for 28 days following the last vaccination. A woman is considered of childbearing potential unless post-menopausal or surgically sterilized. Acceptable contraception methods are restricted to effective devices \[e.g., intrauterine device (IUD), NuvaRing®\] or licensed hormonal products with use of method for a minimum of 30 days prior to vaccination, a monogamous relationship with a vasectomized partner and abstinence from sexual intercourse with men. * Negative enzyme-linked immunosorbent assay (ELISA) for human immunodeficiency vi…