Effect of Platelet Rich Plasma on Photoaged Skin

Inclusion Criteria: Part 1: * Subjects of either gender (M/F), 35-60 years old. * Subjects are in good health. * Subjects who are willing and have the ability to understand and provide informed consent for participation in the study and are able to communicate with the investigator. Part 2: * Subjects of either gender (M/F), 35-60 years old. * Subjects are in good health. * Bilateral cheek wrinkles "in motion" with severities of ≥ type II of Glogau photoaging classification (APPENDIX I). * Subjects who are willing and have the ability to understand and provide informed consent for participation in the study and are able to communicate with the investigator. * Subject requests cosmetic improvement of facial wrinkles. Exclusion Criteria: * Pregnant or lactating. * Subjects who are unable to understand the protocol or to give informed consent. * Subjects who have a self-reported history of blood or platelet disorders e.g. anemia, thrombocytopenia, coagulopathy, hypofibrinogenemia, or are on anticoagulant or antiplatelet therapy. * Subjects who have active skin disease or skin infection in treatment area. Subjects who have a history of hypertrophic scars and keloids. * Subjects who have any requirement for the use of local or systemic steroids or immunosuppressive agents. * Subject notes that he/she is HIV positive * Subjects with history of skin cancer or actinic keratosis * Uncooperative patients or patients with neurological disorders who are incapable of following direc…