CompletedPhase 2

Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty

United States101 participantsStarted 2011-06

Plain-language summary

This study aims to assess postoperative blood loss and transfusion rates in total knee replacement after one-time administration of topical tranexamic acid.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All adult patients over age eighteen * Primary unilateral total knee arthroplasty at Henry Ford Hospital (Detroit, Michigan, United States) and Henry Ford West Bloomfield Hospital (West Bloomfield, Michigan, United States) Exclusion Criteria: * patient history of venous thromboembolic disease or coagulopathy * use of anticoagulant medications within 7 days of surgery * history of arterial embolic disease * history of Class III or IV heart failure * renal failure * intraoperative cardiovascular, pulmonary, orthopaedic, or anesthetic complication (MI, intraoperative fracture, vasopressor support, emergent intubation).

What they're measuring

Blood Loss

Timeframe: participants will be followed for the duration of hospital stay, an expected average of 3 days

Trial details

NCT IDNCT01370460

SponsorHenry Ford Health System

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-09

Results submitted2013-03-27

View on ClinicalTrials.gov More Acute Blood Loss Anemia trials