The Energy Dose Study

Inclusion Criteria: * A signed informed consent is in place on the patient's chart * The patient is at least 18 but not more than 90 years of age at time of ICU admission * The patient has a body mass index (BMI) less than 40 kg/m\^2 * The patient has been admitted to either a medical or surgical (non-neurological) ICU and is expected to survive and remain in the ICU for at least 72 hours after entry * There is central venous access for administration of the study PN * The patient's primary physician(s) will allow the investigative team to manage the study PN and enteral feedings during the current hospitalization * The patient is expected to require total or partial central venous PN for 7 or more subsequent days after entry on a clinical basis Exclusion Criteria: * The patient is pregnant * The patient has unresuscitated clinical sepsis, defined as unstable blood pressure despite vasopressor support and mean arterial pressure (MAP) \< 60 mm Hg on at least 3 consecutive readings within a 3-hour period during the 24 hours prior to study entry * The patient was admitted to the ICU following trauma or burns * The patient has significant renal dysfunction (defined as serum creatinine \> 2.5 mg/dL or deemed to have significant acute kidney injury by the primary physicians) and is not receiving continuous renal replacement therapy (CRRT) or intermittent hemodialysis * The patient has previously undergone an organ transplantation * The patient has a current malignancy or is curr…