Study Evaluating Impact of IL-7 on CD4 Lymphopenia, Risks of Severe Haematological Toxicity and Tumor Progression in Metastatic Breast Cancer Patients

Inclusion Criteria: * Female aged more than 18 years * Histologic diagnosis of metastatic breast cancer to be treated with capecitabine at study entry. NB: Patients previously treated with capecitabine are eligible only if more than 6 months have elapsed since the last capecitabine intake. * Lymphopenic (i.e. with at least one value of lymphocyte count 1500/µL within 15 days before Day 0). * Performance status ECOG of 0, 1,2 or 3 * Life expectancy ≥ 6months * Adequate bone marrow, hepatic and renal function as follows: * Neutrophils ≥ 1,000/µL * Platelets ≥ 100 109/µL * ASAT, ALAT, or Alkaline Phosphatase ≤ 2.5 x ULN * Total Bilirubin ≤ 1.5 x ULN * INR ≤ 1.5 * Calculated creatinin clearance ≥ 60mL/min (Cockcroft formula or MDRD formula for patients older than 65 years old)- Ability to understand and sign informed consent * Covered by a medical insurance. Exclusion Criteria: * Prior history of other malignancies other than breast cancer (except for basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix) unless the subjects has been free of the disease for at least 3 years. * No resolution of specific toxicities related to any prior anti-cancer therapy to Grade ≤2 according to the NCI CTCAE v.4.0 (except lymphopenia, alopecia and neuropathy) * Wash out period of less than 5 times the half-life of previous anti-cancer treatment before study entry, except if previous chemotherapy treatment before study entry. NB: For patient previousl…