Tiotropium in Patients With Tuberculosis (TB) Destroyed Lung

Inclusion Criteria: * previous pulmonary tuberculosis history * never smoker or light smoker (\<10 pack-year) * destruction of lung parenchyme, lung volume loss,secondary bronchiectasis due to tuberculosis in chest radiographs or chest CT, confirmed by board-certificate radiologist * airflow obstruction confirmed by pulmonary function test, FEV1/FVC \<70% Exclusion Criteria: * patients do not agree with study enrollment * patients with active tuberculosis or current antituberculous medication * patients under chemotherapy or other immunosuppressant therapy such as glucocorticoid. * active infection such as pneumonia, tuberculosis * patients who are illiterate * patients with dementia * pregnant or to be pregnant * previous lung resection surgery history