Assessment of Relative Bioavailability of NKTR-118 in Three Formulations in Healthy Subjects

Inclusion Criteria: * Provision of signed and dated, written informed consent prior to any study-specific procedures * Females must have a negative pregnancy test at screening and on admission to the unit, must not be lactating, and must be of non-childbearing potential, confirmed at screening by fulfilling one of the following criteria: * Post-menopausal defined as amenorrhea for at least 12 months following cessation of all exogenous hormonal treatments and with follicle stimulating hormone (FSH) levels in the laboratory defined post-menopausal range * Irreversible surgical sterilization by hysterectomy, bilateral oophorectomy, or bilateral salpingectomy, but not tubal ligation * Volunteers must have a body mass index (BMI) between 18 and 30 kg/m2 and weigh at least 50 kg * Volunteers must be able to understand and be willing to comply with study procedures, restrictions and requirements * Healthy male and non-fertile female volunteers ages 18 to 55 years inclusive, with suitable veins for cannulation or repeated venipuncture Exclusion Criteria: * Any clinically significant disease or disorder (eg, cardiovascular, pulmonary, gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic, malignant, psychiatric, major physical impairment) which, in the opinion of the Investigator, may either put the healthy volunteer at risk because of participation in the study, or influence the absorption, distribution, metabolism, and excretion of drugs * Current s…