Minimal Effective Dose of Nomegestrol Acetate Inhibiting the Ovulation in Women Receiving Estradiol

Inclusion Criteria: * Female premenopausal healthy volunteers having given their informed written consent at the first selection visit, * Registered with Social Security in agreement with the French Law on biomedical research on volunteers, * Sufficiently co-operative to meet the needs of the study, * Accepting not to become pregnant during the trial, * Accepting the use of condoms as the single authorized contraceptive means during the trial, * With a diurnal and regular job or activity, * Aged 18 to 35 years old inclusive, * Non-smokers or current smokers of less than 10 cigarettes/day, * With normal eating habits, * With a body mass index between 17 and 27 inclusive, Exclusion Criteria: * Participation in another clinical trial, * Blood donation in the three months prior to Visit V1 or intention to donate blood during the trial or within the three months following the trial completion, * Virgins, because of the gynecological examination, * Subjects who were within the exclusion period in the Healthy Volunteers National Register of the French Ministry of Health, * Forfeiture of freedom by administrative or legal award or under guardianship, * No possible contact in case of emergency, * Strenuous physical activity planned during the trial. Concerning the gynecological status and examination * History of major medical, psychiatric illness or surgery, * Any acute or chronic systemic disease or disorder, * History of hypersensitivity to at least one drug (abnormal drug react…