Study to Evaluate Analgesic Effect of IV Administration of Kappa Agonist CR845 For Hysterectomy Surgery

Inclusion Criteria: * Able to provide written informed consent prior to any study procedures; * Able to communicate clearly with the Investigator and staff; * Female between 21 and 65 years of age, inclusive; * Scheduled for elective laparoscopic hysterectomy under general anesthesia; * Negative result on serum pregnancy test at screening and negative urine pregnancy test at Baseline (for women of child-bearing potential only) and not currently breast feeding, or planning to do so within 30 days of dosing; * Negative urine drug screen for drugs of abuse at Screening and at Baseline; * American Society of Anesthesiologists (ASA) risk class of I to III; * Body mass index (BMI) between 17 and 40 inclusive. Exclusion Criteria: * Has known allergies to opioids, or hypersensitivity to other materials (such as infusion line) or medications to be used in the study; * Has a known or suspected history of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)-diagnosed alcohol, opiate or other drug abuse or dependence within 12 months prior to screening; * Is unable to refrain from alcohol consumption for a period beginning 24 hours prior to surgery through the end of the Treatment Period; * Is scheduled to undergo a hysterectomy that will utilize any type of robotic technology and/or a concomitant surgical procedure that would produce a significantly greater degree of surgical trauma than the laparoscopic hysterectomy or laparoscopic assisted vaginal hysterec…