TASALL - TachoSil® Against Liquor Leak

Main Inclusion Criteria (Positive response): • Is the surgical approach/procedure consistent with skull base surgery? I.e. one of the following: * Lateral approach to the foramen magnum: Far lateral, extreme lateral, anterolateral, posterolateral * Approach to the jugular foramen: Infratemporal, juxta condylar, transjugular * Approach to the cerebello pontine (CP) angle and petrous apex retrosigmoid * Approach to the middle fossa: Subtemporal (+/- petrous apex drilling), pterional approach (any fronto temporal approach +/- orbitozygomatic deposition) * Approach to the anterior fossa: Subfrontal (uni or bilateral) * Approach to the midline posterior fossa Main Exclusion Criteria (Negative response): * Has the patient been subject to neurosurgery involving opening of the dura mater within the last 3 months? * Is the patient anticipated to undergo any additional neurosurgery involving opening of the dura mater which may affect the efficacy evaluation (e.g. re-operation or anticipation to undergo several neurosurgeries) before the Efficacy Follow-up Week 7±1 week? * Is the patient anticipated to undergo any additional neurosurgery involving opening of the dura mater which may affect the safety evaluation (e.g. re-operation or anticipation to undergo several neurosurgeries) before the Safety Follow-up Week 28±2 weeks? * The surgical approach/procedure is consistent with any transcranial or transfacial or combination of transcranial - transfacial approaches with wide defect in …