Study of Resting and Exercising Body Functioning in Freeman-Sheldon Syndrome and Related Conditions

Syndrome Group Inclusion Criteria: * Freeman-Sheldon syndrome, * Sheldon-Hall syndrome, * Distal arthrogryposis type 1, or * Distal arthrogryposis type 3 * Deceased patients with enough clinical information available to satisfy study requirements Syndrome Group Exclusion Criteria: * Individuals not confirmed to have a condition under study * Deceased patients without enough clinical information available to satisfy study requirements * Patients with other anomalies, not having one of the above syndromes * Patients or parents of minor children not willing to give consent * Mature female patients who are pregnant or breast-feeding will be reassessed for consideration for enrolment. * Mature female patients who are currently experiencing menses will be reassessed for consideration for enrolment. * Patients with active, acute comorbid illness will be reassessed for consideration for enrolment. Control Group Inclusion Criteria: * Subjects must be healthy and free of active disease. * Subject or parent of minor child must be willing to give consent. * Subjects must fall within the age-bracket to be matched with a Syndrome Group patient already screened and enroled in the study * Subjects must be non-tobacco users and non-drinkers. Control Group Exclusion Criteria: * Subjects exceptional for their age in body weight, stature, or habitus according to commonly accepted guidelines * Subjects with active psychiatric illness, as manifested by abnormal mental status examination * S…