Reach for Health Study: Obesity-related Mechanisms and Mortality in Breast Cancer Survivors

Inclusion Criteria: * BMI at least 25.0 kg/m2 * Diagnosed with Stage I, II, or III breast cancer within past 5 years * Treatment with total mastectomy or breast-sparing surgical removal of cancer with clear macroscopic margins, and axillary dissection, followed by adjuvant breast radiation * Not scheduled for or currently undergoing chemotherapy * Accessible geographically and by telephone * Able to communicate dietary and physical activity data via telephone * If taking statins, tamoxifen, or aromatase inhibitors; able and willing to remain on treatment for 6-month study period * Post-menopausal at diagnosis Exclusion Criteria: * Preliminary bloodwork outside of specified ranges * Evidence of renal insufficiency, liver disease, or congestive heart failure * Currently taking corticosteroid pills or steroid hormone therapy (including vaginal estrogen creams) * Recent initiation (\< 3 months ago) of thiazides or β-blockers * Taking insulin or other antidiabetic drug * Other primary or recurrent invasive cancer in past 10 years * Unable to commit to study requirements