A Study Evaluating Skin Irritation, Phototoxicity and Safety After Administration of LEO 90105 on Intact Skin of Healthy Japanese Male Subjects

Inclusion Criteria: * Healthy Japanese male subjects, * Aged 20 to 40 years inclusive. * Subjects without signs of skin irritation (erythema,dryness, roughness or scaling) on test sites. * Subjects willing to follow the study procedures and complete the study Subjects having understood and signed a written informed consent. * Subjects without abnormal in physiological test and clinical test in screening, and also judged as possible to participant the study by investigators. Exclusion Criteria: * Body mass Index (BMI ) (body weight (kg)/height(m)²) outside the range 18-25 kg/m2 * History of alcohol, chemical or drug abuse * History of allergic reaction to drugs or history of skin reaction to the tape * Any systemic or cutaneous disease that could in any way confound interpretation of the study results (e.g. atopic dermatitis, eczema, psoriasis) * Known sensitivity to any component of any of the formulations being tested * Known hepatic or renal disorders * Use of systemic, locally injected or inhaled corticosteroids within 4 weeks of study start (Day 1) * Use of systemic vitamin D analogues, vitamin D or calcium supplements within 4 weeks of study start(Day 1) * Use of any drug (systemic or topical) within 2 weeks of study start (Day 1) * Use of non-marketed/other investigational products one month prior to or 5 half lives (for those the half life is longer than one month) and during the trial is not permitted * Any abnormality found at medical interview before administrati…