Pilot Study of Hepatitis C Virus Entry Inhibitor (ITX 5061) in Liver Transplant Recipients

Inclusion Criteria: * Age ≥ 18 years old, ≤ 65 years old * Plasma HCV RNA positive at time of listing for liver transplantation * Accepted for liver transplantation for any of: * End-stage liver disease due to HCV infection * End-stage liver disease due to HCV infection and alcohol related liver disease (ALD) * HCC due to HCV Exclusion Criteria: * Refusal or inability to give informed consent * Viral co-infection with either hepatitis B virus (HBV) or human immunodeficiency virus (HIV) * Pregnancy or breastfeeding * Women, of child-bearing potential, who are not willing to practice effective contraception * Men, sexually active with women of child-bearing potential, who are not willing to practice effective contraception * Any situation that in the Investigator's opinion may interfere with optimal study participation * Participation in any clinical study of an investigational agent within 30 days of recruitment * Transplantation with a donor organ from a HCV positive individual