PureGen: Radiographic Analysis of Fusion for ACDF

Inclusion Criteria: * Persistent neck and/or arm pain consistent to symptomatic cervical degenerative disc disease * Moderate Neck Disability Index * Unresponsive to conservative treatment for at least 6 weeks Exclusion Criteria: * More than 4 levels requiring surgical treatment * Prior failed fusion surgery at the index level(s) * Systemic or local infection in the disc or cervical spine, past or present * Active systemic disease * Osteoporosis, osteomalacia, or other metabolic bone disease that would significantly inhibit bone healing * Known or suspected history of alcohol and/or drug abuse * Involved in pending litigation or worker's compensation relating to the spine * Pregnant or plans to become pregnant during the duration of the study * Insulin-dependent diabetes mellitus * Life expectancy less than study duration * Any significant psychological disturbance that in the opinion of the Investigator could impair consent process or ability to complete self-assessment questionnaires * BMI greater than 40 * Undergoing chemotherapy or radiation treatment, or chronic use of oral or injected steroids or prolonged use of non-steroidal anti-inflammatory drugs * Known history of hypersensitivity or anaphylactic reaction to dimethyl sulfoxide (DMSO).