Pilot Study of Hyperthermic Peritoneal Perfusion (HIPEC) for Adolescent and Young Adults With Des… (NCT01277744) | Clinical Trial Compass
CompletedPhase 2
Pilot Study of Hyperthermic Peritoneal Perfusion (HIPEC) for Adolescent and Young Adults With Desmoplastic Small Round Cell Tumor
United States22 participantsStarted 2011-05-09
Plain-language summary
The goal of this clinical research study is to learn if heated intra-abdominal cisplatin can help to control abdominal tumors in patients having surgery to remove the tumors. The safety of this drug will also be studied.
Who can participate
Age range1 Year
SexALL
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Inclusion criteria
✓. Age greater than or equal to 1 years
✓. Histologically or genetically proven diffuse peritoneal or retroperitoneal tumor from desmoplastic round cell tumor, ovarian germ cell, sarcoma, Wilms' tumor, or other non-carcinoma tumors.
✓. Radiologic workup must demonstrate that the disease is confined to the abdominal cavity
✓. Radiologic workup or prior abdominal exploration must be consistent with disease which can be debulked to a residual size of less than or equal to 1 cm thickness per tumor deposit
✓. Patients must have a minimum expected duration of survival of greater than 6 weeks as determined and documented by the attending surgeon or medical oncologist.
✓. Patients must not have any systemic illness which precludes them from being an operative candidate as determined by anesthesia preoperative evaluation. This includes but is not limited to, sepsis, liver failure, pregnant or lactating females.
✓. Patients must have fully intact mental status and normal neurologic abilities. Intact mental status is defined by 'the capacity to identify and recall one's identity and place in time and space.' Assessment of mental status and documentation of fully intact mental status will be completed using physical and mental exam by the referring doctor or oncologist.
✓. Patients must have adequate renal function (serum creatinine \</= 1.5 mg/dl without history dialysis or renal failure or creatinine clearance less than 50 mL/min/1.73M\^2 if less than 5 years of age)
Exclusion criteria
✕
What they're measuring
1
Recurrence Free Survival
Timeframe: 36 months after the last participant enrolled
. Patients will be ineligible if they have any concomitant cardiopulmonary disease which would place them at unacceptable risk for a major surgical procedure
✕. Patients will be ineligible if they have disease outside of the abdominal cavity which is uncontrolled
✕. Patients will be ineligible if they have a baseline neurologic toxicity of Grade 3 or greater (because of the potential neurotoxicity associated with platinum)
✕. Patients who have failed previous intraperitoneal platinum therapy will be ineligible
✕. Patients with Retroperitoneal Liposarcoma will be ineligible.