GP2013 in the Treatment of RA Patients Refractory to or Intolerant of Standard Therapy

Inclusion Criteria: * Rheumatoid arthritis as defined by the 1987 ACR classification * Severe active seropositive disease * Inadequate response or intolerance to other DMARDs and anti-TNFs * Treatment with Methotrexate Exclusion Criteria: * Patients with systemic manifestations of rheumatoid arthritis * Female patients nursing * Women of childbearing potential unless using birth control * Active infection * Known immunodeficiency syndrome * Positive Hepatitis B surface antigen or antibodies to Hepatitis C * History of cancer Other protocol-defined inclusion/exclusion criteria may apply