Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma (NCT01258998) | Clinical Trial Compass
CompletedPhase 2
Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma
United States60 participantsStarted 2010-12
Plain-language summary
This phase II clinical trial studies how well Akt inhibitor MK2206 works in treating patients with relapsed lymphoma. Akt inhibitor MK2206 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Histologically confirmed Hodgkin lymphoma (HL) or non-Hodgkin lymphoma (NHL) (small lymphocytic lymphoma may be included)
* Relapsed or refractory after at least one regimen and with no curative option with conventional therapy
* Bidimensionally measurable disease (at least 2 cm)
* No evidence of cerebral or meningeal involvement by lymphoma
* Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1
* Signed informed consent form prior to enrollment
* Women of childbearing potential and men must use two forms of contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a women become pregnant or suspect she is pregnant while she or her partner is participating in this study, the patient should inform the treating physician immediately
Exclusion Criteria:
* Burkitt's lymphoma, lymphoblastic lymphoma, chronic lymphocytic leukemia and cutaneous T-cell lymphoma
* Chemotherapy or radiation therapy or other investigational agents within 3 weeks prior to entering the study unless there is clear evidence of progression of disease and toxicity from previous treatment has resolved in which case study entry may be within 1 week of last treatment
* Previous radioimmunotherapy within 12 weeks
* Patients with known immunodeficiency virus (HIV) infection must not have cluster of differentiation (CD)4 cells \< 400/mm\^3 and who must not have a prior acquired immunodefici…