Study of Alternative Vaccination Schedule of Oral Cholera Vaccine

Healthy, non-pregnant adults aged 18 years and above and healthy children aged 1 - 17 will be recruited in Kolkata. Inclusion Criteria: * Males or non-pregnant females aged 18 years and above and children aged 1 -17 years who the investigator believes will comply with the requirements of the protocol (i.e. available for follow-up visits and specimen collection). * Written informed consent obtained from the subjects or their parents/guardians, and written assent for children aged 12 - 17 years. * Healthy subjects as determined by: * Medical history * Physical examination * Clinical judgment of the investigator Exclusion Criteria: * Ongoing serious chronic disease * For females of reproductive age: Pregnancy (or females planning to become pregnant during the study period; as determined by verbal screening) * Immunocompromising condition or therapy (for corticosteroids this would mean ≥0.5 mg/kg/day) * Diarrhea (3 or more loose/watery stools within a 24-hour period) 6 weeks prior to enrollment * One or two episodes of diarrhea lasting for more than 2 weeks in the past 6 months * One or two episodes of abdominal pain lasting for more than 2 weeks in the past 6 months * Intake of any anti-diarrhea medicine in the past week * Abdominal pain or cramps, loss of appetite, nausea, general ill-feeling or vomiting in the past 24 hours * Acute disease one week prior to enrollment, with or without fever. Temperature ≥38ºC warrants deferral of the vaccination pending recovery of …