AIMSPRO in the Treatment of Bladder Dysfunction in Secondary Progressive Multiple Sclerosis

Inclusion Criteria: * M / F aged 18 years or older. * Patients of childbearing potential must use adequate birth control measures for the duration of the study and 6 months after receiving the last injection of AIMSPRO. * Clinically definite SPMS. * Ambulant, walking aids allowed. * No more than one relapse within the last 12 months and no relapse within the last 6 months. * Urinary frequency of at least 8 times per 24-hours. * Urinary urgency with or without urge incontinence. * MRI brain or spinal cord abnormalities consistent with MS. * Screening laboratory test results must meet the following criteria: * Haemoglobin \> 9.5 g/dL * WBC \> 3.5 x 109/L * Neutrophils \> 1.5 x 109/L * Platelets \> 100 x 109/L * Baseline AST , alkaline phosphatase, Thyroid function, Serum Electrophoresis levels must be within the normal range. * Able to adhere to the study visit schedule and other protocol requirements * Capable of giving written informed consent. Exclusion Criteria: * Acute symptomatic urinary infection. * Taking DDAVP or antimuscarinic agents. * Full time wheelchair user. * Immunosuppressant drug therapy of any kind in the last 3 months. * Relapse within the last 6 months. * No clear progression of disability in the last 12 months. * Co-existent medical condition precluding participation, including any history of severe allergic reaction. * Pregnant or lactating women and women who are planning pregnancy within 12 months of screening (i.e., approximately 6 months f…