The purpose of this study is to assess the long-term efficacy and safety of latanoprost monotherapy in patients with normal tension glaucoma (NTG) using a prospective, observational design. Visits were scheduled at 6-month intervals for 24 months. Intraocular pressure (IOP), optic nerve head findings, visual field status, and adverse events were recorded.
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Change From Baseline in Raw Intraocular Pressure (IOP) by Visit
Timeframe: Baseline, Month 6, Month 12, Month 18, Month 24, Last Visit
Number of Participants With a 24-Hour Intraocular Pressure (IOP) Profile: Month 12
Timeframe: Month 12
Number of Participants With a 24-Hour Intraocular Pressure (IOP) Profile: Month 24
Timeframe: Month 24
Number of Participants Per Visit With Intraocular Pressure (IOP) 24-Hour Pressure Peaks: Month 12
Timeframe: Month 12
Number of Participants Per Visit With Intraocular Pressure (IOP) 24-Hour Pressure Peaks: Month 24
Timeframe: Month 24
Percentage of Participants Who Achieved Intraocular Pressure (IOP) Target at Last Visit
Timeframe: Month 24, (or last visit)
Change From Baseline by Visit in Optic Disc Excavation: Horizontal Cup to Disc Ratio
Timeframe: Baseline, Month 6, Month 12, Month 18, Month 24, Last Visit
Change From Baseline by Visit in Optic Disc Excavation: Vertical Cup to Disc Ratio
Timeframe: Baseline, Month 6, Month 12, Month 18, Month 24, Last Visit
Number of Participants With Optic Disc Hemorrhage by Visit: Month 6
Timeframe: Month 6
Number of Participants With Optic Disc Hemorrhage by Visit: Month 12
Timeframe: Month 12
Number of Participants With Optic Disc Hemorrhage by Visit: Month 18
Timeframe: Month 18
Number of Participants With Optic Disc Hemorrhage by Visit: Month 24
Timeframe: Month 24
Change From Baseline in Heidelberg Retina Tomograph (HRT) Parameters: Rim Area
Timeframe: Baseline, Month 6, Month 12, Month 18, Month 24, Last Visit
Change From Baseline in Heidelberg Retina Tomograph (HRT) Parameters: Rim Volume
Timeframe: Baseline, Month 6, Month 12, Month 18, Month 24, Last Visit
Change From Baseline in Heidelberg Retina Tomograph Parameters: Cup Shape Measure
Timeframe: Baseline, Month 6, Month 12, Month 18, Month 24, Last Visit
Change From Baseline in Heidelberg Retina Tomograph (HRT) Parameters: Mean RNFL Thickness
Timeframe: Baseline, Month 6, Month 12, Month 18, Month 24, Last Visit
Number of Participants With Change From Baseline to Month 24 in Aulhorn Stages
Timeframe: Baseline, Month 24
Number of Participants With Change From Baseline to Month 24 in Visual Field Defect
Timeframe: Baseline, Month 24
Number of Participants With Investigator Assessments of Efficacy at Month 24
Timeframe: Month 24
Number of Participants With Individual Progression of Glaucoma Damage: Horizontal Cup to Disc Ratio and/or Vertical Cup to Disc Ratio
Timeframe: Month 24 (or last visit)
Number of Participants With Individual Progression of Glaucoma Damage: Optic Disc Hemorrhage
Timeframe: Month 24 (or last visit)
Number of Participants With Individual Progression of Glaucoma Damage: Rim Area, Rim Volume, or Mean Retinal Nerve Fiber Layer (RNFL) Thickness
Timeframe: Month 24 (or last visit)
Number of Participants With Individual Progression of Glaucoma Damage: Visual Field Defect-Deterioration
Timeframe: Month 24 (or last visit)
Number of Participants With Individual Progression of Glaucoma Damage: Aulhorn Stage
Timeframe: Month 24 (or last visit)
Number of Participants With Individual Progression of Glaucoma Damage: Mean Defect
Timeframe: Month 24 (or last visit)
Percentage of Participants With Overall Progression of Glaucoma Damage
Timeframe: Month 24 (or last visit)
Percentage of Participants With Progression of Optic Disc Excavation
Timeframe: Month 24 (or last visit)
Percentage of Participants With Progression of Visual Field
Timeframe: Month 24 (or last visit)