CompletedNot Applicable

Prognostic Factors of Acute Splenic Sequestration

France58 participantsStarted 2010-08-12

Plain-language summary

Acute splenic sequestration is a frequent and life threatening complication occurring in approximately 10 % of homozygous children. Maximal incidence is between 6 and 18 months. The investigators formulate the hypothesis that there are clinical, biological and genetic markers predictive of severe complications notably acute splenic sequestration in SCD children. The present research project thus aims at analyzing in a forward-looking way the profile of severity by analysing clinical, biological and genetic characteristics in a multicentric cohort of 60 SCD children

Who can participate

Age range3 Months – 6 Months

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria : * Children aged 3 to 6 months * homozygous (SS) or S beta° sickle cell disease diagnosed by neonatal screening * With no history of acute splenic sequestration * Signed parental consent * Patient covered by national insurance scheme or CMU Exclusion criteria : * Children with other SCD genotype * Children with congenital anatomical asplenia * Children with previous episode of acute splenic sequestration * Absence of possible follow-up * Simultaneous enrolment in another biomedical research

What they're measuring

Study of prognostic factors of acute splenic sequestration

Timeframe: after three years

Trial details

NCT IDNCT01207037

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-12-22

View on ClinicalTrials.gov More Anemia; Drepanocytic trials