WithdrawnNot Applicable

Optimizing Ovulation Induction in the Poor Responder

Stopped: Change in staffing

United States0Started 2010-10

Plain-language summary

The purpose of this randomized controlled trial is to compare the efficacy and effect of luteal estradiol and combined oral contraceptive pills (COPC) on follicle recruitment and synchrony in a poor responder population. The randomized groups consist of: 1. patients receiving luteal estradiol prior to ovulation induction; and 2. patients receiving COCPs for 1 month prior to ovulation induction. Follicle characteristics and serum biomarkers will be followed and compared in each group. Coefficient of variation will be used to evaluate follicle size discrepancy. Chi square analysis will be used to compare categorical variables between treatment groups. Both estradiol and COPCs are used clinically in assisted reproduction, so this study affords no additional risks to the participants.

Who can participate

Age range20 Years – 50 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Antral follicle count \< 8 * Antimullerian hormone (AMH) \<1.3 * Follicle stimulating hormone (FSH)\>10 * History of follicular dysynchrony or poor response Exclusion Criteria: * Menopause * FSH \>40 * Age \> 50 * Contraindication to estradiol or COCP (including pre-existing cardiovascular disease, familial thrombophilia (factor V Leiden), severe hypercholesterolemia, smoker over age 35) Ovulation induction during month of estradiol treatment

What they're measuring

Follicular response and synchrony

Timeframe: 2 years

Trial details

NCT IDNCT01200537

SponsorDuke University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2011-10

View on ClinicalTrials.gov More IVF Poor Responders trials